What is Sipple syndrome?
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Sipple’s syndrome is a generally familial polyneoplastic affection associating a medullary thyroid cancer and a pheochromocytoma. The overall picture of the syndrome has, in fact, become larger now that it is known that there is previous hyperplasia of thyroid C cells and chromaffin cells in relation to neoplasms.
What is mucosal neuroma?
Mucosal neuromas are benign tumors of nerve tissue that are a characteristic feature of multiple endocrine neoplasia type 2B (also known as MEN3), a hereditary syndrome associated with the development of medullary thyroid cancer.
What is multiple endocrine neoplasia type 2?
Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition associated with 3 primary types of tumors: medullary thyroid cancer, parathyroid tumors, and pheochromocytoma. MEN2 is classified into subtypes based on clinical features. MEN2A, which affects 95% of MEN2 families.
Can men2 be cured?
Because MTC can be cured by surgical removal of the thyroid, prompt diagnosis of this condition is essential to prevent the cancer from spreading.
What is Pollock disease?
Nasal polyps are soft, noncancerous growths on the lining of your nose or sinuses. They often occur in groups, like grapes on a stem. Nasal polyps are soft, painless, noncancerous growths on the lining of your nasal passages or sinuses.
What is medullary thyroid?
Medullary thyroid cancer, or MTC, is a cancer that forms in the thyroid. The thyroid is a gland located in the front of your neck, just below the Adam’s apple. It is responsible for sending out hormones to the rest of your body. The inside of the thyroid is called the medulla.
How do you test for MEN2?
Genetic testing is the mainstay in the diagnosis of multiple endocrine neoplasia type 2 (MEN2) syndromes. Perform genetic screening for RET mutations in all index patients. If a mutation is identified, also screen family members who are at risk.
What is a ganglioneuroma?
Ganglioneuroma is a tumor of the autonomic nervous system. Ganglioneuromas are rare tumors that most often start in autonomic nerve cells. Autonomic nerves manage body functions such as blood pressure, heart rate, sweating, bowel and bladder emptying, and digestion. The tumors are usually noncancerous (benign).
How is ganglioneuroma diagnosed and treated?
Blood and urine tests may be done to determine if the tumor is producing hormones or other chemicals. A biopsy or complete removal of the tumor may be needed to confirm the diagnosis. Treatment involves surgery to remove the tumor (if it is causing symptoms). Most ganglioneuromas are noncancerous. The expected outcome is usually good.
Who is at risk for ganglioneuroma?
Ganglioneuromas usually occur in people over 10 years of age. They grow slowly, and may release certain chemicals or hormones. There are no known risk factors. However, the tumors may be associated with some genetic problems, such as neurofibromatosis type 1.
Does ganglioneuroma come back after surgery?
A ganglioneuroma may become cancerous and spread to other areas. It may also come back after it is removed. If the tumor has been present for a long time and has pressed on the spinal cord or caused other symptoms, surgery to remove the tumor may not reverse the damage.