What is Sp1 binding site?
Table of Contents
The binding site of Sp1 has been known to be a ‘GC box’, with the consensus sequence 5′-(G/T)GGGCGG(G/A)(G/A)(C/T)-3′ (9). In some promoter sequences the GC box is often arranged as a tandemly repeated array and Sp1 binds to such a sequence with cooperative bending of the DNA (8,10).
Where is Sp1 expressed?
mucous neck region
We found that Sp1 protein was expressed predominantly in the nuclei of cells located in the mucous neck region, whereas Sp1 expression was not detected either in the cells located toward the gastric pit (foveolar differentiation) or cells of the glandular epithelium (glandular differentiation).
What type of transcription factor is Sp1?
Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis.
What is ATF biology?
ATF forensic biologists use cutting-edge technology to collect and analyze biological evidence from crime scenes to help solve violent crimes involving firearms, explosives or arson.
What does Windows 7 Sp1 mean?
Service Pack 1
INTRODUCTION. Service Pack 1 (SP1) for Windows 7 and for Windows Server 2008 R2 is now available. This service pack is an update to Windows 7 and to Windows Server 2008 R2 that addresses customer and partner feedback.
What is the structure of SP1?
Structure. SP1 belongs to the Sp/KLF family of transcription factors. The protein is 785 amino acids long, with a molecular weight of 81 kDa. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys 2 /His 2 type and bind…
Why is SP1 used as a control protein?
Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level.
How many SP-1 binding sites are in the human genome?
Some 12,000 SP-1 binding sites are found in the human genome. Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level.
What is the Sp1 transcription factor (SP1) gene?
Szpirer J, Szpirer C, Riviere M, Levan G, Marynen P, Cassiman JJ, et al. (September 1991). “The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7”.