What is the difference between Xgeva and Zometa?
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Xgeva is approved to help prevent broken bones in people with multiple myeloma. This is a form of cancer that affects your bone marrow (the tissue in your bones). Zometa is approved to treat bone metastases in multiple myeloma when used with a type of anticancer drug called an antineoplastic.
Which is better zoledronic acid or denosumab?
Denosumab and zoledronic acid are both bone-modifying agents that prevent the occurrence of SREs. Denosumab has been shown to be superior to zoledronic acid in delaying SREs in various types of cancer, such as breast cancer, lung cancer, and multiple myeloma.
Is there a substitute for Xgeva?
Xgeva Alternatives Compared
| Xgeva denosumab | Zometa zoledronic acid | Denosumab |
|---|---|---|
| Dosage Form(s) Available | ||
| Subcutaneous solution | Intravenous solution | N/A |
| Brand Names | ||
| Other denosumab brands include: Prolia | Other zoledronic acid brands include: Aclasta, Reclast | Prolia, Xgeva |
When was Zometa discontinued?
Novartis ceased manufacturing ZOMETA (zoledronic acid for injection), EQ 4 mg-base/vial, lyophilized powder for injection, in May 2003.
Is Xgeva considered chemotherapy?
XGEVA®, also called denosumab, is prescribed for people with bone metastases from breast, prostate, and other solid tumors (cancer) and for people with multiple myeloma. XGEVA® is not chemotherapy or other treatment for your cancer.
How long can you stay on Xgeva?
Xgeva concentrations reach a steady level within three to six months. Xgeva reduced levels of the bone turnover marker, uNTx/Cr by 82% after one week in patients with breast cancer and bone metastases, and by 75% after five weeks in patients with newly diagnosed multiple myeloma.
Is denosumab better than Zometa?
A study has found that Xgeva (chemical name: denosumab), a targeted therapy medicine, is better than Zometa at reducing the risk of a skeletal-related event in women diagnosed with metastatic breast cancer that has spread to the bones. The study also found Xgeva improved quality of life more than Zometa.
Is denosumab better than bisphosphonates?
Denosumab has a greater antiresorptive effect than bisphosphonates. The effects of bisphosphonates for preventing bone loss mainly need bisphosphonates binding to bone mineral. Denosumab mainly through direct combined with the RANKL and inhibit the survival and differentiation of osteoclast.
How much does a shot of Xgeva cost?
The cost for Xgeva subcutaneous solution (120 mg/1.7 mL) is around $2,764 for a supply of 1.7 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What happens when you stop taking Xgeva?
Before you stop Xgeva treatment, it’s important to talk with your doctor. If you stop receiving the drug, it’s possible to develop hypercalcemia or bone fractures. To decrease your risk of these problems, your doctor may monitor your blood levels. (Too much calcium in your blood could harm your bones.)
Why do you need dental clearance for Zometa?
Dental Preclearance and Careful Tracking Can Prevent Osteonecrosis of the Jaw Due to Bisphosphonates. Bisphosphonates are an important part of managing bony metastasis of prostate, breast, lung, and other cancers but can cause osteonecrosis of the jaw (ONJ) in some patients.
Is there a generic for Zometa?
Zoledronic acid is the generic name for the trade name drug Zometa®. In some cases, health care professionals may use the trade name Zometa® when referring to the generic drug name zoledronic acid.
Is Xgeva better than Zometa?
Xgeva Better Than Zometa at Reducing Risk of Bone Problems in Women With Metastatic Disease. Zometa (chemical name: zoledronic acid) is used to strengthen bones in women diagnosed with metastatic breast cancer that has spread to the bones. Zometa also is used to lower their risk of a skeletal-related event.
What is Xgeva?
Zometa zoledronic acid Xgeva is an injection that is administered every four weeks to prevent bone fractures in people with certain types of cancer or to lower calcium levels in people with high calcium levels caused by…
What is Zometa used to treat?
Zometa (chemical name: zoledronic acid) is used to strengthen bones in women diagnosed with metastatic breast cancer that has spread to the bones. Zometa also is used to lower their risk of a skeletal-related event.
How common is osteonecrosis of the jaw with Xgeva?
Osteonecrosis of the jaw developed in 2.5% of the women treated with Xgeva and in 1.8% of the women treated with Zometa. Xgeva also may cause severe hypocalcemia, very low blood calcium levels, which can be life-threatening.