What is Mcl-1 gene?

What is Mcl-1 gene?

MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Chlamydia. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein and Interleukin-4 and 13 signaling.

How does MCL-1 inhibit apoptosis?

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor types and is closely associated with tumorigenesis, poor prognosis and drug resistance.

What does Mcl-1 stand for?

Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human primary and drug-resistant cancer cells makes it an attractive cancer therapeutic target.

What is an Mcl-1 inhibitor?

An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.

What is MCL lead ECG?

MCL 1 or Modified V1. Another popular monitoring lead is the MCL1 lead (or modified V1). To connect this lead, the negative electrode is placed near the left shoulder, usually under the outer third of the left clavicle, and the positive electrode is placed to the right of the sternum in the fourth intercostal space.

What is a modified chest lead?

A modified chest lead system is proposed to provide more information about the electrical activity of the atria in normal subjects. ECG trace were recorded and analyzed simultaneously for the subjects with the proposed modified chest leads and the conventional bipolar limb leads in the CRO.

What does MCL stand for heart?

MCL is an abbreviation for medial collateral ligament.

Where do chest leads go?

12-lead Precordial lead placement

• V1: 4th intercostal space (ICS), RIGHT margin of the sternum.
• V2: 4th ICS along the LEFT margin of the sternum.
• V4: 5th ICS, mid-clavicular line.
• V3: midway between V2 and V4.
• V5: 5th ICS, anterior axillary line (same level as V4)
• V6: 5th ICS, mid-axillary line (same level as V4)

Is Mcl-1 a rapidly and acutely regulated protein?

Discussion Evidence is accumulating that Mcl-1 is a protein whose contribution to cell fate is rapidly and acutely regulated, through changes in transcription, localisation, stability and its ability to form dimers with Bcl-2 homologues and other proteins.

What is the role of Mcl-1 in apoptosis?

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria. Mcl-1 has a short half life and is a highly regulated protein, induced by a …

Mcl-1 – discovery and characterisation Mcl-1 (myeloid cell leukemia 1) is a pro-survival member of the Bcl-2 family that was initially identified as an immediate-early gene expressed during PMA-induced differentiation of ML-1 myeloid leukemia cells [3].

What makes Mcl-1 unique among the Bcl-2 family?

The N-terminus of Mcl-1 is unique amongst the Bcl-2 family, in that it is rich in experimentally confirmed and putative regulatory residues and motifs. These include sites for ubiquitination, cleavage and phosphorylation, which influence the protein’s stability, localisation, dimerization and function.