Can an amorphous material experience polymorphism?
Table of Contents
Recent studies of amorphous solid materials have revealed the possibility that more than one distinct amorphous phase may be formed from the same substance. In analogy with the phenomenon of crystalline polymorphism, this behavior has been termed “amorphous polymorphism”.
What is polymer polymorphism?
Polymorphism is the ability of a polymer, in analogy with low molecular mass substances, to crystallize in different modifications, characterized by different crystal structures (polymorphic forms). 1-6 Almost all crystalline polymers show polymorphic behavior.
Why is the study of polymorphism important for pharmaceutical compounds?
Polymorphism is an influential phenomenon especially in pharmaceutical sciences, as it can significantly influence variety of API properties including flowability, tableting, dissolution rate, solubility, stability and even biological performance including efficacy and toxicity [4, 88-90].
What are the factors affecting polymorphism?
The most important internal factors are polymorphism, which depends on variation in fatty acid moieties, and the composition or blending of different lipid materials. Important external factors are thermal treatment, additives, application of shear, sonication, and pressure.
How do you differentiate polymorphism?
Polymorphism is that in which we can perform a task in multiple forms or ways. It is applied to the functions or methods. Polymorphism allows the object to decide which form of the function to implement at compile-time as well as run-time.
How does polymorphism affect drug properties?
Due to the differences in crystal structure, different polymorphs of a given solid drug show different physicochemical characteristics, which may lead to different drug bioavailability and half-life of the drug.
How is polymorphism formed?
polymorphism, in crystallography, the condition in which a solid chemical compound exists in more than one crystalline form; the forms differ somewhat in physical and, sometimes, chemical properties, although their solutions and vapours are identical.
How do you identify polymorphism?
Gel Electrophoresis. Gel electrophoresis is most widely adapted technique for detecting polymorphism. Samples are loaded into a gel and allowed to migrate in an electric field. Since DNA is negatively charged, the samples are loaded near the negative pole, and they migrate toward the positive pole.
What is polymorphism in chemistry?
Polymorphism is the ability of a solid material to exist in more than one crystal structure. Solids tend to be ordered and different spatial three-dimensional arrangements of the same molecules can give us different crystal structures, so different polymorphs.
What is amorphous morphology of polymers?
Polymers with an amorphous morphology have their atoms held together in a loose structure, but this structure is never orderly or predictable, which is why chemists will say that amorphous solids have no long-range order. To understand this better, think of a polymer chain as a piece of spaghetti.
Can polymeric solids be amorphous and crystalline at the same time?
What’s more, some polymeric solids can be both amorphous and crystalline at the same time. This surprising idea is particularly important to the study of polymers. In this article, we’ll explain the difference between amorphous and crystalline polymers and provide some common examples of each.
Can more than one amorphous phase be formed from one substance?
Recent studies of amorphous solid materials have revealed the possibility that more than one distinct amorphous phase may be formed from the same substance. In analogy with the phenomenon of crystalline polymorphism, this behavior has been termed “amorphous polymorphism”.