What is epithelioid cell granulomas?

What is epithelioid cell granulomas?

Epithelioid cell granuloma can be defined as specifically and structurally organized collection of epithelioid cells, macrophages, lymphocytes and dendritic cells.

What type of infection does the presence of a granuloma indicate?

Granulomas are most commonly associated with mycobacterial and fungal infections but can also occur with other infections, including Epstein-Barr virus (EBV),21 leishmaniasis, toxoplasmosis,22 brucellosis,23 and Q fever.

What do Langhans cells do?

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.

What causes giant cell granuloma?

Central giant cell granuloma is a fairly common lesion in the jaws aetiology of which is still completely unknown but thought to be of a reactive process to some unknown stimuli. It usually arises either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone.

What is Langhans giant cell granuloma?

A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages that are transformed into epithelium like cells surrounded by a collar of mononuclear leukocytes, principally lymphocytes, and plasma cells.[1,2,3] Langhans giant cells are multinucleated giant cells present in numerous diseases.

Are Langhans giant cells specific for tuberculosis (TB)?

Although traditionally their presence was associated with tuberculosis, they are not specific for tuberculosis or even for mycobacterial disease. In fact, they are found in nearly every form of granulomatous disease, regardless of etiology. Langhans giant cells are named after Theodor Langhans (1839–1915), a German pathologist.

What is giant granuloma with multinucleated giant cells?

Granuloma formation with multinucleated giant cells is seen in numerous diseases. A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells.

What is granuloma of the lung?

… A granuloma is the result of chronic inflammation and consists of a microscopic aggregation of macrophages transformed into epithelioid cells, surrounded by a collar of lymphocytes and plasma cells.