How effective is carboplatin and pemetrexed?
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Objective response rates were 26.8% for pemetrexed/oxaliplatin patients and 31.6% for pemetrexed/carboplatin patients. Median time to progression was 5.5 and 5.7 months for pemetrexed/oxaliplatin and pemetrexed/carboplatin, respectively. Median overall survival was 10.5 months for both treatment groups.
What is pemetrexed plus carboplatin?
Abstract. Chemotherapy with pemetrexed plus carboplatin followed by pemetrexed maintenance therapy is a first-line regimen for patients with advanced non-squamous non-small-cell lung cancer.
What is Abraxane carboplatin?
ABRAXANE is a prescription medicine used to treat advanced non–small cell lung cancer, in combination with carboplatin, in people who cannot be treated with surgery or radiation. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 .
How often is pemetrexed given?
You usually have pemetrexed and carboplatin as cycles of treatment. Each cycle of treatment lasts 21 days (3 weeks). Depending on your cancer, you may have between 4 and 6 cycles of treatment, taking about 4 months in total. You have pemetrexed as a drip into your bloodstream over 10 minutes.
Is pemetrexed effective?
Pemetrexed, a multitarget antifolate, is effective in non-squamous NSCLC and malignant pleural mesothelioma, with the main focus on inhibition of enzymes involved in pyrimidine and purine synthesis such as thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) …
Do you lose your hair with pemetrexed?
LESS COMMON SIDE EFFECTS OF PEMETREXED Your hair may thin out, though it is unlikely you will lose all of the hair on your head. Hair loss normally starts after your first or second cycle of chemotherapy. It is almost always temporary, and the hair will continue to grow after you finish your chemotherapy.
What is pemetrexed and carboplatin used for?
What is pemetrexed and carboplatin? Pemetrexed and carboplatin is a combination treatment used to treat mesothelioma and non-small cell lung cancer (NSCLC). It is best to read this information with our general information about chemotherapy and the type of cancer you have.
How many times can you take carboplatin + pemetrexed?
On occasion, carboplatin + pemetrexed may be given in the hospital if someone is too sick. Carboplatin + pemetrexed is repeated every 21 days. This is known as one Cycle. Each cycle may be repeated up to 6 times.
Is pemetrexed-carboplatin a useful treatment for advanced non-squamous cell carcinoma (NSCLC)?
In advanced NSCLC, pemetrexed use is restricted to non-squamous histology. The combination pemetrexed-carboplatin could be a valuable treatment option in elderly patients. Neutropenia was the most common toxicity. The ORR is within the range of data reported for pemetrexed-carboplatin in the general NSCLC population (24-31%).
What is the discontinuation rate for carboplatin + pemetrexed?
On average, 1 – 13% of patients discontinue carboplatin + pemetrexed due to unacceptable side effects. Note: when hair loss occured, patients kept most of their hair, and hair loss was not obvious from a distance.