What level is Depakote toxicity?
Its action is similar to that of other common anticonvulsants, such as phenytoin and carbamazepine. The therapeutic range for valproic acid is 50-100 mcg/mL. The toxic level is >100 mcg/mL.
Does Depakote cause carnitine deficiency?
It has been hypothesized that valproic acid may induce a carnitine deficiency in children and cause nonspecific symptoms of deficiency, hepatotoxicity, and hyperammonemia.
What are the signs of Depakote toxicity?
Key signs and symptoms include: CNS depression, lethargy and encephalopathy, respiratory depression, nausea/vomiting and myoclonus. Laboratory abnormalities are particularly helpful in this case.
How is Depakote toxicity treated?
Treatment / Management Therapy for patients with valproate toxicity is mainly supportive and includes initial stabilization and resuscitation. Measures include maintenance of airway, breathing, and circulation. Establish early IV access as intravenous fluid administration for the patients presenting with hypotension.
When should you draw a Depakote level?
It is recommended that trough levels for the DR version be drawn immediately prior to the morning dose, assuming a twice-daily dosing strategy. For once-daily divalproex ER regimens, the ideal time to draw serum levels is immediately prior to the next scheduled dose.
Can you overdose on carnitine?
Are there health risks from too much carnitine? At doses of approximately 3 g/day, carnitine supplements can cause nausea, vomiting, abdominal cramps, diarrhea, and a “fishy” body odor [1,2]. Rarer side effects include muscle weakness in uremic patients and seizures in those with seizure disorders.
Is L-carnitine good for epilepsy?
The panelists concurred that oral L-carnitine supplementation is strongly suggested for the following groups as well: patients with certain secondary carnitine-deficiency syndromes, symptomatic VPA-associated hyperammonemia, multiple risk factors for VPA hepatotoxicity, or renal-associated syndromes; infants and young …
What is the antidote for Depakote?
Naloxone. Naloxone is a pure competitive opioid antagonist used for reversal of respiratory depression after opioid exposure.
Does Depakote raise ammonia levels?
The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe.
What is too much Depakote?
An overdose of Depakote could be fatal, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Overdose symptoms can include irregular heartbeat, sleepiness, and loss of consciousness resulting in a coma.