Which is the initial test for detection of rifampicin resistance?
The Xpert® MTB/RIF (Xpert) is an automated molecular test for simultaneous detection of tuberculosis (TB) and rifampicin resistance, recommended by the World Health Organization as the preferred diagnostic method for individuals presumed to have multi-drug resistant TB (MDR-TB) or HIV-associated TB.
Which drug is used to treat cases of tuberculosis?
Isoniazid (INH): This is the most common therapy for latent TB. You typically take an isoniazid antibiotic pill daily for 9 months. Rifampin (Rifadin, Rimactane): You take this antibiotic each day for 4 months. It’s an option if you have side effects or contraindications to INH.
What is rifampicin resistance?
Rifampicin-resistant TB (RR-TB) defined as resistance to rifampicin detected using genotypic or phenotypic methods with or without resistance to other first-line anti-TB drugs. MDR-TB/RR-TB has been an area of growing concern to human health worldwide and posing a threat to the control of TB.
How do you deal with tuberculosis?
If you have an active TB disease you will probably be treated with a combination of antibacterial medications for a period of six to 12 months. The most common treatment for active TB is isoniazid INH in combination with three other drugs—rifampin, pyrazinamide and ethambutol.
What is MTB detected?
It means normal tuberculosis medication can be given to the patient.
What is the duration of treating new cases of TB?
RIPE regimens for treating TB disease have an intensive phase of 2 months, followed by a continuation phase of either 4 or 7 months (total of 6 to 9 months for treatment). This is the preferred regimen for patients with newly diagnosed pulmonary TB.
How is rifampicin resistance detected?
Rifampin resistance is particularly amenable to detection by rapid genotypic assays because 95% of all rifampin-resistant strains contain mutations localized in an 81-bp region of the bacterial RNA polymerase gene, rpoB, which encodes the active site of the enzyme (14, 21).