What does Fmoc stand for chemistry?
Table of Contents
The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile protecting group used in organic synthesis.
What is a scavenger in peptide synthesis?
These reaction steps involve hydrolysis with hydrogen fluoride (HF) in the presence of a nucleophile (scavenger), whose function is to trap the carbocations produced during SN 1-type reactions. Five peptide sequences were synthesised for evaluating p-methoxyphenol effectiveness as a potent scavenger.
What is FMOC synthesis?
In Fmoc solid-phase peptide synthesis, the peptide chain is assembled stepwise, one amino acid at a time, while attached to an insoluble resin support. This allows the reaction by-products to be removed at each step by simple washing.
How do I remove the Fmoc?
The Fmoc group is, in general, rapidly removed by primary (i.e., cyclohexylamine, ethanolamine) and some secondary (i.e., piperidine, piperazine) amines, and slowly removed by tertiary (i.e., triethylamine [Et3N], N, N-diisopropylethylamine [DIEA]) amines.
What does Fmoc stand for Target?
Federal Funds Target Range – Upper Limit (DFEDTARU) Download
| 2022-03-22: | 0.50 |
|---|---|
| 2022-03-21: | 0.50 |
| 2022-03-20: | 0.50 |
| 2022-03-19: | 0.50 |
| 2022-03-18: | 0.50 |
What type of scavenger would you use for solid phase synthesis?
Another report uses a macroporous, highly crosslinked poly(styrene-divinylbenzene) as a base matrix for solid phase scavengers (Scheme 2). This matrix is superior to Merrifield resins when nonwetting solvents such as acetonitrile are used. A 12-membered test library of sulfonamides was generated in high purity (2).
How is an excess of reagent removed in a solid phase chemical reaction?
Excess reagents are removed after each reaction by washing the fluorous material with organic solvents. Solid phase synthesis limits the choice of solvents to those that swell the resin.