What is an MMP enzyme?

What is an MMP enzyme?

Matrix metalloproteinases (MMPs) are a group of enzymes that in concert are responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover.

What is MMP substrate?

Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

What is MMP collagenase?

MMP-1 is a collagenase that cleaves collagen types I, II, III, VII, and X at one site in the helical structure [140]. It is well known to be overexpressed in various cancer cells during the invasion and metastasis phases [141].

What are MMP-2 and MMP-9?

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases, and MMP-2 and MMP-9 are major members of the MMP family (6,7). MMP-2 and MMP-9 are mainly secreted by tumor cells and stromal cells in the form of zymogens.

How do MMPs degrade collagen?

The monoclonal antibody recognizes a 6 amino acid sequence at position 764 in the C-terminus of type 1 collagen (Leeming et al., 2011b). The collagen degradation fragment is generated by MMPs 2, 9 and 13 and is destroyed by cathepsin K, making this a soft tissue specific marker not originating from bone turnover.

What is MMP medical?

Matrix metalloproteinases (MMPs) are members of an enzyme family that require a zinc ion in their active site for catalytic activity. MMPs are critical for maintaining tissue allostasis.

What is MMP 13 enzyme and neuropathy?

The involvement of MMP-13 in both neuropathies and its conservation in mice indicates that the mechanism may be conserved among sensory neuropathies and translate into humans. Therefore, selective MMP-13 inhibitor applications to the epidermis may be a valuable treatment option for diabetic neuropathy.