What does IL 1 beta do?
Table of Contents
The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury.
Is IL 1 an antibody?
IL-1 beta Polyclonal Antibody.
Is Il 1b proinflammatory?
Interleukin-1 β is a proinflammatory cytokine that modulates neurotoxic neurotransmission and prolongs kainate-induced seizures by enhancing glutamatergic neurotransmission (347).
Is Il beta a cytokine?
Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.
Does IL-1 cause inflammation?
IL-1β is a pro-inflammatory cytokine that has been implicated in pain, inflammation and autoimmune conditions. This review will focus on studies that shed light on the critical role of IL-1β in various pain states, including the role of the intracellular complex, the inflammasome, which regulates IL-1β production.
Is IL-1 pro-inflammatory?
IL-1β is potent pro-inflammatory cytokine, induced mainly by lymphocytes, macrophages, and monocytes in response to microbial molecules.
How do I lower my IL-1?
All biological agents currently used for reducing TNFalpha activity in disease are neutralization strategies; however, there are several strategies for reducing interleukin (IL)-1 activities: the IL-1 receptor antagonist (IL-1Ra), anti-IL-1beta monoclonal antibodies, the IL-1 Trap, IL-1 receptor type I antibodies.
How can I reduce my IL-1?
What is IL-1 beta antibody?
IL-1 beta Antibody detects endogenous levels of both the 31 kDa precursor and 17 kDa mature form of IL-1 beta. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of the 17 kDa mature form of human IL-1 beta.
What is the concentration of interleukin 1 beta (IL-1 beta) after filtration?
Filtration: 0.2 µm post-manufacturing filtered. Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol.
How does p420b detect IL-1 beta?
P420B targets IL-1 beta in ELISA, IHC, Neu, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples. The P420B immunogen is recombinant human IL-1 beta. P420B detects IL-1 beta which has a predicted molecular weight of approximately 31 kDa.
What is the detection limit for recombinant mouse IL-1 beta?
When used in conjunction with compatible development reagents, the detection limit for recombinant mouse IL-1 beta is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. Lanes 1-11: 250, 125, 62.5, 31.25, 15.625, 7.8, 3.9, 1.95, 0.975, 0.4875 and 0.24 ng recombinant mouse IL-1 beta, respectively.