What is Myc Myc?

What is Myc Myc?

MYC was initially identified as the target oncogene dysregulated by the t (8;14) (q24;q32) translocation in Burkitt lymphoma (BL).

What is the role of Myc in transcription?

The transcriptional program regulated by MYC includes 10% to 15% of all human genes. The main cell functions and pathways under control of MYC are cell proliferation and growth, DNA replication, protein biosynthesis, and regulation of metabolism and energy.

Does Myc oncogenic activation promote escaped protein response?

Interestingly, MYC oncogenic activation also seems to promote the unfolded protein response in transformed cells as a mechanism to escape from its apoptotic effects. 88

What is the role of Myc in the pathophysiology of follicular lymphoma?

Most aggressive lymphomas with MYC alterations are related to follicular lymphoid cells, but the role of MYC in GC formation and maintenance has been elusive until recently. 27, 28 MYC is expressed in mature B cells initiating GC formation and in a small subpopulation of B cells of the light zone of the GC.