What is the difference between vildagliptin and sitagliptin?

What is the difference between vildagliptin and sitagliptin?

The reason for the differences in drug efficacy (mean blood glucose level and MAGE) observed in this study is considered to be that sitagliptin 50 mg daily results in less than 70% suppression of DPP-4 activity over 24 h [20] whereas vildagliptin 50 mg twice daily results in 80% or greater suppression of DPP-4 activity …

What is the difference between saxagliptin & vildagliptin?

Conclusion Vildagliptin produced a significantly greater reduction in acute glucose fluctuations compared with saxagliptin when added to a dual combination of metformin and sulfonylurea in Chinese patients with T2DM.

Which is better sitagliptin or linagliptin?

The results showed that the efficacy of the two drug regimens was the same. Conclusions: Based on the results, there was no significant difference between the two drugs, i.e. linagliptin and sitagliptin, in terms of efficacy; in other words, the efficacy of the two drugs was the same.

What are the benefits of vildagliptin as compared to other gliptins?

Conclusions: These results indicate that vildagliptin ameliorates insulin sensitivity and non-HDL-C levels in subjects with high degrees of insulin resistance and vildagliptin also shows glycemic efficacy by decreasing HbA1c. This is not the case with teneligliptin though similar glycemic efficacies were observed.

What is the difference between vildagliptin and metformin?

At end-point, vildagliptin was as effective as metformin, improving HbA1c by -0.64+/-0.07% and -0.75+/-0.07%, respectively, meeting the predefined statistical criterion for non-inferiority (upper limit of 95% confidence interval for between-treatment difference

Which is better teneligliptin or sitagliptin?

Conclusion: Teneligliptin provided similar glycemic control as compared to sitagliptin and reduced HbA1c, FBG and PPBG values significantly within 12 weeks of treatment. Both gliptins were found to be safe and well-tolerated in Indian patients with T2DM.

Which is better Teneligliptin or sitagliptin?

Is linagliptin better than sitagliptin?

What is the difference between linagliptin and sitagliptin?

How does vildagliptin 50 mg work for type 2 diabetes?

Vildagliptin 50 mg administered twice daily to patients with type 2 diabetes mellitus significantly lowered the mean 24-h blood glucose level measured by CGM, MAGE, the highest blood glucose levels after dinner, and hyperglycemia after breakfast, compared with sitagliptin 50 mg administered once daily.

What are the parameters of glucose variability in vildagliptin patients?

Parameters of glucose variability in patients taking vildagliptin (100 mg daily) or sitagliptin (50 mg daily) The mean 24-h blood glucose level was significantly lower in patients taking vildagliptin than patients taking sitagliptin (p = 0.012) during both the night (00:00 to 08:00) and the day (08:00 to 24:00).

Does vildagliptin reduce HbA1c and FPG?

HbA1c was reduced by 0.54% in patients treated with vildagliptin and 0.56% in patients treated with sitagliptin. Similarly, there was no significant difference in FPG change between the two groups. FPG decreased by 0.47 mmol/l with vildagliptin.

What is the difference between sitagliptin 50 mg and 100 mg?

Combining matched trials, vildagliptin 50 mg twice daily was associated with significantly greater absolute HbA(1c) reduction by 0.28% compared with sitagliptin 50 mg once daily (95% CI 0.15, 0.41; p < 0.001) and by 0.35% compared with sitagliptin 100 mg once daily (95% CI 0.07, 0.62; p = 0.013).