What is the normal level of HDL in the blood?

What is the normal level of HDL in the blood?

What are optimal levels of HDL cholesterol?

	At risk	Desirable
Men	Less than 40 mg/dL (1.0 mmol/L)	60 mg/dL (1.6 mmol/L) or above
Women	Less than 50 mg/dL (1.3 mmol/L)	60 mg/dL (1.6 mmol/L) or above

What was the target of therapy of torcetrapib?

The inhibition of this protein raises HDL-C levels and also reduces LDL-C levels. The concept of raising HDL-C levels through pharmacological intervention of this target was validated in preclinical and clinical studies with torcetrapib, the first CETP inhibitor to be assessed in late-stage clinical trials.

At what level is HDL protective?

As defined by the US National Cholesterol Education Program Adult Treatment Panel III guidelines, an HDL-C level of 60 mg/dL or greater is a negative (protective) risk factor. On the other hand, a high-risk HDL-C level is described as being below 40 mg/dL.

Should I worry if my HDL is high?

Higher HDL levels are associated with a lower risk of heart disease. HDL levels lower than 40 milligrams per deciliter (mg/dL) are considered worrisome, and levels higher than 60 mg/dL are considered excellent.

How high is too high HDL?

What is a good triglyceride number?

A simple blood test can reveal whether your triglycerides fall into a healthy range: Normal — Less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L) Borderline high — 150 to 199 mg/dL (1.8 to 2.2 mmol/L) High — 200 to 499 mg/dL (2.3 to 5.6 mmol/L)

What is considered high HDL?

HDL cholesterol levels greater than 60 milligrams per deciliter (mg/dL) are high. That’s good. HDL cholesterol levels less than 40 mg/dL are low.

Does torcetrapib increase HDL cholesterol?

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that has been shown to increase HDL cholesterol levels by >50%.40 In a large prospective randomized trial, 40 torcetrapib increased HDL cholesterol levels by 61% but had no effect on progression of coronary atherosclerosis.

How effective is torcetrapib in patients at high risk for coronary events?

Effects of Torcetrapib in Patients at High Risk for Coronary Events 1 Results. At 12 months in patients who received torcetrapib, there was an increase… 2 Conclusions. Torcetrapib therapy resulted in an increased risk of mortality and morbidity… 3 Methods. We conducted a prospective, randomized, multicenter, double-blind clinical trial,…

What is torcetrapib used to treat?

Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP), which transfers cholesterol from HDL cholesterol to VLDL or LDL cholesterol (159R). Inhibition of this process increases HDL concentrations and reduces LDL concentrations (160C–162C).

Does torcetrapib have an off-target effect on CETP inhibition?

Torcetrapib therapy resulted in an increased risk of mortality and morbidity of unknown mechanism. Although there was evidence of an off-target effect of torcetrapib, we cannot rule out adverse effects related to CETP inhibition. (ClinicalTrials.gov number, NCT00134264 .)