Can L-glutamine make anxiety worse?
It appears that glutamine is unlikely to be an effective natural anxiety treatment, but that more research is needed. Keep in mind that excess GABA can be problematic as well, so studies may show that L-Glutamine has a negative effect on anxiety instead.
Does glutamine help you sleep?
Most people tend to produce GABA from glutamine, and thus glutamine would help them sleep, but for someone who is prone to convert glutamine to glutamic acid, a glutamine supplement late in the day would actually interfere with sleep.

What does glutamine do in the brain?
In the central nervous system, brain glutamine is the major substrate for the generation of both excitatory and inhibitory neurotransmitters (glutamate and γ-aminobutyric acid).
Is glutamine safe for kidneys?
A review by Sacks (1999) concluded that glutamine is safe, with the possible exception of specific patient groups such as those with liver or kidney disease and preterm neonates.
Does glutamine have any side effects?

In fact, even cancer patients rarely experience side effects from taking glutamine. The authors of a March 2017 report in Support Care Cancer tested 56 children with cancer and found that only 2 percent of them had glutamine-related problems during a three-week study.
What are the side effects of L-glutamine?
The side effects of the L-glutamine supplement include dangerous increases in ammonia. Glutamine is the most abundant amino acid circulating throughout your body, according to a December 2015 report in Nature Cell Biology. It plays an important role in creating a healthy balance throughout your organ systems.
What is glutamine used for?
Glutamine is an amino acid that affects the processes of growth and function of cells in the stomach and intestines. Glutamine is a medical food product that is used to supplement dietary sources of glutamine. glutamine is used to treat a glutamine deficiency, or a loss of glutamine caused by injury or illness.
What are the long-term effects of feeding glutamine to burn victims?
Administering glutamine through a feeding tube seems to reduce the risk of developing severe infections and might reduce the chance of death in people with severe burns. Administering glutamine intravenously (by IV) seems to decrease the risk of some infections in people with severe burns. But it does not seem to decrease the risk of death.