How is red cell aplasia treated?
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Corticosteroids: Corticosteroid treatment in the form of oral prednisone is considered the mainstay of therapy for pure red cell aplasia. A corticosteroid helps the bone marrow make more red blood cells.
Is red cell aplasia curable?
Acquired Pure Red Cell Aplasia usually goes into remission when certain drugs such as sulfonylureas (used for treating diabetes), gold for treatment of arthritis, penicillin, phenytoin and phenobarbitol used for treating epilepsy, or the anesthetic halothane which can cause this disorder are discontinued.
What is parvovirus induced pure red cell aplasia?
Abstract. Parvovirus B19 infection causes chronic anaemia in immunodeficient individuals by selective suppression of erythropoiesis. The bone marrow morphology is characteristic of pure red cell aplasia (PRCA). To determine the frequency of B19-induced PRCA we retrospectively analysed a series of 57 PRCA patients.
Can parvovirus cause aplastic anemia?
Human parvovirus B19 (B19 virus) infection is known to induce aplastic crisis in patients with hemolytic anemia. In healthy subjects, B19 infection may sometimes cause mild pancytopenia, but these changes are transient and recovery is spontaneous.
What drugs cause red cell aplasia?
With these criteria, phenytoin, azathioprine, and isoniazid had sufficient evidence of causality. All three are documented causes of PRCA and should be considered in any case of selective erythrocyte aplasia.
What drugs can cause red cell aplasia?
What is the treatment for parvovirus?
For an uncomplicated parvovirus infection, self-care treatment at home is generally sufficient. People with severe anemia may need to stay in the hospital and receive blood transfusions. Those with weakened immune systems may receive antibodies, via immune globulin injections, to treat the infection.
Can erythropoietin be given IV?
Recombinant human erythropoietin (epoetin-α) treatment increases blood hemoglobin levels in almost all patients with anemia of ESRD and has been a mainstay of managing these patients for decades (1–6). Both intravenous (iv) and subcutaneous (sc) epoetin effectively ameliorate anemia of kidney failure.
How is pure red cell aplasia (PRCA) treated?
Another well-documented cause of pure red cell aplasia is a chronic parvovirus B19 infection, which may be seen in immunocompromised hosts. The treatment of this cause of PRCA includes removal of immunosuppression, intravenous immunoglobulin (IVIg), or rituximab; however, this condition may also be self-limiting.
What is the best treatment for parvovirus B19?
IVIg has been found to be an effective therapy for chronic parvovirus B19 infection. Commercial IVIg is known to contain IgG antibodies to parvovirus B19, which can control and may even eradicate B19 infection. 11-13 This therapy was successful in bringing about a resolution of anemia in our patient.
What is the treatment for thymoma associated with Parvovirus infection (PRCA)?
The treatment of PRCA associated with thymoma, B19 parvovirus infection, ABO-incompatible stem cell transplantation, antibody-mediated inhibition induced by rhEpo, or pregnancy will be discussed later. DBA is typically treated with glucocorticoids, usually prednisone.
Is Parvovirus B19 the etiologic factor in rituximab-associated red cell aplasia?
To our knowledge, this is the first case report of pure red cell aplasia associated with the use of rituximab therapy, which implicates parvovirus B19 as the etiologic factor linking the two. Aspects of this case may provide leads into diagnostic and therapeutic decision making for similar patients encountered in the future.