What are coagulation disorders in pregnancy?

What are coagulation disorders in pregnancy?

Obstetric patients undergo many physiological changes that impact haemostasis, in addition to congenital and acquired disorders of coagulation. Major issues include von Willebrand disease, factor deficiencies, anticoagulant therapy, and massive haemorrhage.

What conditions in pregnancy can cause acquired coagulopathy?

The patient may have developed a coagulopathy acutely secondary to hemodilution, disseminated intravascular coagulation (DIC), or ALFP (Acute Fatty Liver of Pregnancy) Additional reasons for postpartum hemorrhage include placenta accreta, HELLP syndrome and amniotic fluid embolism.

What are the APTT values in pregnancy?

Normal Value Range

• Adult Negative Pregnancy: 26.3 to 39.4 Seconds.
• Pregnancy Trimester One: 24.3 to 38.9 Seconds.
• Pregnancy Trimester Two: 24.2 to 38.1 Seconds.
• Pregnancy Trimester Three: 24.7 to 35.0 Seconds.

What happens to coagulation factors in pregnancy?

Most blood coagulation factors and fibrinogen increase during pregnancy. Factor (F) XI is the only blood coagulation factor that decreases. Blood coagulation inhibitors are mainly unchanged but the level of free protein S decreases markedly and the level of tissue factor pathway inhibitor increases.

What can cause acquired coagulopathy?

Acquired coagulopathy can be associated with either hemorrhagic or thrombotic tendency, and triggered by a variety of underlying disease processes including traumatic injury, surgical procedures, liver failure, autoimmune disease, chronic inflammation, and infections.

Is aPTT and PTT the same?

Description. Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT) are used to test for the same functions; however, in aPTT, an activator is added that speeds up the clotting time and results in a narrower reference range.

What blood clotting disorder causes miscarriages?

Thrombophilia is any health condition which increases your risk of developing abnormal blood clots. If you are pregnant or plan on becoming pregnant, thrombophilias can lead to a number of complications, including miscarriage and stillbirth.

What is thromboelastography®?

Thromboelastography®(TEG®) provides a global ‘bedside’ test of haemostatic coagulation from a single blood sample. Current laboratory tests, e.g. platelet count, prothrombin time and activated partial thromboplastin, measure individual components of the pro-thrombotic – anti-thrombotic process.

Why is thromboprophylaxis not given to women with Te during pregnancy?

An unknown positive family history for TE disease or an undiagnosed thrombophilia, the later having been implicated in up to 50% of TE in pregnancy and postpartum women,13may not be identified. This lack of identification may result in thromboprophylaxis not being given to women during their pregnancy.

What is rotational thromboelastometry (ROTEM)?

Wikkelsø A, Wetterslev J, Møller AM, Afshari A. Thromboelastography (TEG) or rotational thromboelastometry (ROTEM) to monitor haemostatic treatment in bleeding patients: a systematic review with meta-analysis and trial sequential analysis. Anaesthesia. 2017 Apr;72(4):519-531.

Is Coagulation Index a predictor of venous thromboembolism in gynecological oncology?

Liu J, Wang N, Chen Y, Lu R, Ye X. Thrombelastography coagulation index may be a predictor of venous thromboembolism in gynecological oncology patients. J Obstet Gynaecol Res. 2017 Jan;43(1):202-210. [PubMed: 27762468] 53.