What is secretory breast carcinoma?
Table of Contents
Secretory carcinoma of the breast is an extremely rare subtype of breast cancer characterized by intracellular or extracellular secretion and granular eosinophilic cytoplasm of the neoplastic cells.
What are the two most common breast carcinomas and describe each of them?
Invasive breast cancer (ILC or IDC) Invasive (or infiltrating) breast cancer has spread into surrounding breast tissue. The most common types are invasive ductal carcinoma and invasive lobular carcinoma. Invasive ductal carcinoma makes up about 70-80% of all breast cancers.
What is the most common histologic type of breast carcinoma?
Results. Ductal tumors, the most common histological type, accounted for 81.4% of all cases, followed by lobular tumors (6.3%) and unspecified carcinomas (5.5%). Other subtypes accounted for 0.4%-1.5% of the cases each. For all histological types, the proportions differed significantly by age at diagnoses.
What is secretory disease?
Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer . It was originally referred to as “juvenile breast carcinoma” because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages.
What is a secretory Tumour?
Secretory carcinoma is a very rare subtype of breast carcinoma. These tumors are generally associated with a favorable prognosis, although having triple-negative phenotype (estrogen receptor (ER), progesterone receptor (PR) negative and c-erbB2 (HER2) negative).
Is HER2 negative a good thing?
In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.
What is Nottingham score?
The Nottingham histologic score (or histologic grade) is simply a scoring system to assess the “grade” of breast cancers. The grade is a way to rate how aggressive a tumor may behave. Nottingham is a total of 3 different scores.
Are breast cancers adenocarcinomas?
Most types of breast cancers are adenocarcinomas of the breast. These types of tumors are found in many other common cancers and form in glands or ducts that secrete fluid. Breast adenocarcinomas form in milk-producing glands called lobules or in milk ducts.
Summary Summary. Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer. It was originally referred to as “juvenile breast carcinoma” because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages.
Why is it called juvenile breast carcinoma?
It was originally referred to as “juvenile breast carcinoma” because it was first recognized in children and adolescents. [1] [2] However, many cases reported in the last several decades have occurred in adults of all ages. [1] [3] SBC may occur in males or females but like other types of breast cancer, it is much more common in females.
Which findings at autopsy are characteristic of Juvenile Papillomatosis?
The contralateral breast at autopsy showed findings indicative of juvenile papillomatosis. The second case is that of an 18-year-old girl who had multiple juvenile secretory carcinomas in the left breast associated with juvenile papillomatosis.