What are MCF-7 cell lines?

What are MCF-7 cell lines?

MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27].

What are MCF-7 ADR cells?

MCF-7/ADR cells have been widely used as a multidrug-resistant breast cancer cell model in cancer research. The origin of MCF-7/ADR has been a matter of debate since MCF-7/ADR cells were re-designated NCI/ADR-RES in 1998.

Are MCF-7 cells epithelial?

MCF-7 is an adherent, epithelial luminal cell line positive for estrogen and progesterone receptors. Although they are referred to as hormone-dependent, the minimal amount of steroid hormones present in serum is sufficient to ensure cell growth.

What does the acronym MCF-7 represent?

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers.

Is MCF-7 a gene?

In microarray profiles, the MCF-7 gene set clusters with the luminal subtype of breast cancer. MCF-7 xenografts express wild-type p53 and are nonmetastatic even when implanted orthotopically into the mammary fat pad.

What is the MCF-7 cell line?

MCF-7 is a cell line that was first isolated in 1970 from the breast tissue of a 69-year old Caucasian woman. Of the two mastectomies she received, the first revealed that the removed tissue was benign.

What is the pathophysiology of MCF 7?

MCF-7 is an adherent, epithelial luminal cell line positive for estrogen and progesterone receptors. Although they are referred to as hormone-dependent, the minimal amount of steroid hormones present in serum is sufficient to ensure cell growth.

What is MCF-7 breast cancer?

MCF-7 breast cancer cells are estrogen E2-sensitive cells expressing high levels of ERα transcripts and very low levels of ERβ. MCF7 cells increase expression of estrogen receptor (ER) in the absence of estrogens.

Are MCF-7 cells sensitive to cytokeratin?

MCF-7 cells commonly used in research for estrogen receptor (ER)-positive breast cancer cell experiments and various subclones that have been developed represent different classes of ER+ tumors with varying expression level of receptors. In addition to retaining estrogen sensitivity, MCF-7 cells are also sensitive to cytokeratin.