What does cholesterol ester hydrolase do?

What does cholesterol ester hydrolase do?

7.3 Cholesterol esterase ChE hydrolyzes many fatty acid esters of cholesterol. The rate of hydrolysis is greater for long-chain than for short-chain fatty acid esters and is greater for unsaturated than for saturated fatty acid esters.

What is the importance of cholesterol esterase reaction?

Cholesterol esterase (CHE, EC 3.1. 1.13) is an important steroidal enzyme that catalyzes the hydrolysis of cholesterol esters into cholesterol and fatty acids. It is one of the important enzymes for the clinical detection of total serum cholesterol.

What is cholesterol esterification?

Cholesterol Esterification and Hydrolysis. Intracellular cholesterol esterification, catalyzed by the enzyme ACAT (see previous discussion), is an important mechanism to prevent excessive cellular levels of FC, which can be toxic to cells.

What is the purpose for cholesterol esterase enzyme in cholesterol test?

Background. Pancreatic cholesterol esterase has three proposed functions in the intestine: 1) to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to incorporation of cholesterol into mixed micelles; and 3) to aid in transport of free cholesterol to the enterocyte.

What is cholesteryl ester storage disease?

Cholesteryl ester storage disease (CESD) is a type of lysosomal acid lipase (LAL) deficiency; a rare genetic disorder characterized by a deficiency of the lysosomal acid lipase (LIPA or LAL) enzyme. This enzyme is essential for hydrolysis of triglycerides and cholesteryl esters in lysosomes.

Is cholesterol an ester?

Cholesteryl ester, a dietary lipid, is an ester of cholesterol. The ester bond is formed between the carboxylate group of a fatty acid and the hydroxyl group of cholesterol. Cholesteryl esters have a lower solubility in water due to their increased hydrophobicity.

What is lysosomal acid lipase deficiency?

Lysosomal acid lipase deficiency (LALD) is caused by mutations in the LIPA gene. LALD results from a deficiency of an enzyme, lysosomal acid lipase that is necessary for cholesterol metabolism. Patients with LALD often have a buildup of LDL and other lipids which are abnormally stored in the cells.