What is enfuvirtide used for?
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Enfuvirtide is used along with other medications to treat human immunodeficiency virus (HIV) infection. Enfuvirtide is in a class of medications called HIV entry and fusion inhibitors. It works by decreasing the amount of HIV in the blood.
What is the mechanism of action of zidovudine?
Mechanism of action AZT works by selectively inhibiting HIV’s reverse transcriptase, the enzyme that the virus uses to make a DNA copy of its RNA.
What is enfuvirtide target?
Enfuvirtide works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected. A biomimetic peptide, enfuvirtide was designed to mimic components of the HIV-1 fusion machinery and displace them, preventing normal fusion.
Is enfuvirtide a protease inhibitor?
Enfuvirtide (Fuzeon) is an HIV fusion inhibitor, the first drug in a new class of antiretrovirals. The HIV protease inhibitors ritonavir and saquinavir both inhibit cytochrome P450 (CYP450) isoenzymes, and low-dose ritonavir is often used to boost pharmacokinetic exposure to full-dose protease inhibitors.
Is enfuvirtide FDA approved?
Enfuvirtide (brand name: Fuzeon) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and in children 6 years of age and older weighing at least 24 lb (11 kg) whose infection is not well-controlled by ongoing treatment with other HIV medicines.
What is the chemical name of zidovudine?
1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione[1]Zidovudine / IUPAC ID
What is the mechanism of action of enfuvirtide?
Mechanism of action. A biomimetic peptide, enfuvirtide was designed to mimic components of the HIV -1 fusion machinery and displace them, preventing normal fusion. Drugs that disrupt fusion of virus and target cell are termed entry inhibitors or fusion inhibitors .
What is the empirical formula of enfuvirtide?
The empirical formula of enfuvirtide is C204H301N51O64, and the molecular weight is 4492. and the following structural formula: The drug product, FUZEON (enfuvirtide) for Injection, is a white to off-white, sterile, lyophilized powder. Each single-use vial contains 108 mg of enfuvirtide for the delivery of 90 mg.
Where did enfuvirtide come from?
Enfuvirtide originated at Duke University, where researchers formed a pharmaceutical company known as Trimeris. Trimeris began development on enfuvirtide in 1996 and initially designated it T-20. In 1999, Trimeris entered into partnership with Hoffmann-La Roche to complete the development of the drug.
What is Enfuvirtide (INN)?
Enfuvirtide ( INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV -1 infection. It is marketed under the trade name Fuzeon ( Roche ). Enfuvirtide is a 36-amino acid peptide with the following sequence: