What do bisphosphonates do for osteogenesis imperfecta?
Osteogenesis imperfecta is caused by a genetic defect resulting in an abnormal type I collagen bone matrix which typically results in multiple fractures with little or no trauma. Bisphosphonates are used in an attempt to increase bone mineral density and reduce these fractures in people with osteogenesis imperfecta.
What treatments are available for osteogenesis imperfecta?
What are the treatments for osteogenesis imperfecta (OI)?
- Fracture care.
- Physical therapy.
- Surgical procedures.
- Treatments for Related Conditions.
What is pamidronate disodium used for?
Pamidronate is used to treat high blood calcium levels and certain bone problems (bone metastases/lesions) that may occur with some types of cancer. It is also used to treat a certain type of bone disease (Paget’s disease) that causes abnormal and weak bones.
What is the recommended treatment for severe osteogenesis imperfecta?
To date, there is no known treatment, medicine, or surgery that will cure osteogenesis imperfecta (OI). The goal of treatment is to prevent deformities and fractures and allow the child to function as independently as possible.
How long can you take pamidronate?
How long pamidronate is given for. If you are having pamidronate to reduce pain or strengthen your bones, you may continue it for as long as it helps manage the symptoms. If pamidronate is given to lower calcium levels, it is usually given as a single dose. Or you may be given several infusions over 2 to 4 days.
Can you prevent brittle bone disease?
Preventing bone fractures is key for people with OI. They can lower their risk of broken bones by: avoiding activities that put them at risk for a fall or collision, or put too much stress on the bones. doing low-impact exercises (such as swimming) to build muscle strength and mobility and increase bone strength.
How is pamidronate used to treat Osteogenesis Imperfecta in children?
Pamidronate to Treat Osteogenesis Imperfecta in Children. Pamidronate, an aminobisphosphonate, is a potent inhibitor of bone resorption. The purpose of this protocol is to evaluate the effectiveness of pamidronate in children with types III and IV osteogenesis imperfecta when the cycle time is varied.
What is pamidronate used to treat?
Pamidronate strengthens the bone by increasing bone density and corrects the imbalance between bone reabsorption and bone formation which occurs in osteogenesis imperfecta (OI). Pamidronate infusions are most effective when they are given every six weeks in small children and three-monthly in older children.
How many mg of pamidronate disodium are in a vial?
DESCRIPTION Pamidronate Disodium Injection is a bone resorption inhibitor available in 30 mg vials for intravenous administration. Each mL contains 3 mg of pamidronate disodium; 47 mg of mannitol USP and water for injection q.s.; phosphoric acid and/or sodium hydroxide have been added to adjust pH 6.2 to 7.0.
How long does it take for pamidronate to work for osteogenesis imperfecta?
Pamidronate in children with osteogenesis imperfecta: histomorphometric effects of long-term therapy The gains that can be achieved with pamidronate treatment appear to be largely realized in the first 2-4 yr. The gains that can be achieved with pamidronate treatment appear to be largely realized in the first 2-4 yr.