What is Thymoglobulin used for?
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Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a purified polyclonal immunoglobulin used for prevention and treatment of acute rejection (AR) following renal transplantation. Thymoglobulin is mostly used for treating vascular, steroid-resistant and antibody-mediated rejection.
When should Thymoglobulin premedication be given?
Premedication with corticosteroids, acetaminophen, and/or an antihistamine 1 hour prior to each infusion of THYMOGLOBULIN is recommended and may reduce the incidence and intensity of infusion-associated reactions [see Warnings and Precautions (5.2, 5.3); Adverse Reactions (6.1)].
Is Thymoglobulin an immunosuppressant?
THYMOGLOBULIN® (anti-thymocyte globulin [rabbit]) is a purified, pasteurized, immunoglobulin G, obtained by immunization of rabbits with human thymocytes. This immunosuppressive product contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes.
What is the generic name for Thymoglobulin?
GENERIC NAME: LYMPHOCYTE IMMUNE GLOBULIN, ANTI-THYMOCYTE GLOBULIN (RABBIT) – INJ (LIM-foe-site, AN-ti THIGH-mow-site)
What is Thymoglobulin induction therapy?
Abstract. Background: Induction therapy is used to reduce the incidence of graft rejection and delayed graft function. Thymoglobulin is the most used inductor agent in deceased donor kidney transplantation due to its lower rejection and delayed graft function rates.
What are the side effects of Thymoglobulin?
Nausea, fever, chills, diarrhea, dizziness, headache, or tiredness may occur. Redness, pain, or swelling at the injection site may also occur. If any of these effects persist or worsen, tell your doctor promptly. People using this medication may have serious side effects.
Does Thymoglobulin increase blood pressure?
low levels of white blood cells (leukopenia) headache. abdominal pain. high blood pressure (hypertension)…
| Frequently Reported Events | THYMOGLOBULIN n=82 | Active Comparator n=81 |
|---|---|---|
| Headache | 33 (40%) | 28 (35%) |
| Abdominal pain | 31 (38%) | 22 (27%) |
| Hypertension (elevated blood pressure) | 30 (37%) | 23 (28%) |
| Nausea | 30 (37%) | 23 (28%) |
How is Antithymocyte globulin administered?
Administer the first dose within 24 hours before or after the transplant. Treatment of Rejection: The first dose of ATGAM can be delayed until the diagnosis of the first rejection episode. The recommended dose is 10 to 15 mg/kg daily for 14 days. Additional alternate-day therapy up to a total of 21 doses can be given.
What is rabbit thymoglobulin?
Thymoglobulin is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Thymoglobulin is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.
What is Thymoglobulin?
• THYMOGLOBULIN is an immunoglobulin G indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. (1) • Use in conjunction with concomitant immunosuppression .
What is the half-life of thymoglobulin?
a half-life of 2-3 days after the first dose, and 87 mcg/mL (23 -170 mcg/mL) after the last dose. During the THYMOGLOBULIN Phase 3 randomized trial for the treatment of acute rejection, of
What is the typical dosage of Thymoglobulin for a kidney transplant?
receiving a kidney transplant is 1.5 mg/kg of body weight administered daily with the first dose initiated prior to reperfusion of the donor kidney. The usual duration of administration is 4 to 7 days. Treatment of Acute Rejection The recommended dosage of THYMOGLOBULIN for treatment of acute rejection in patients
What is the recommended dosage of Thymoglobulin for treatment of acute rejection?
The recommended dosage of THYMOGLOBULIN for treatment of acute rejection in patients receiving a kidney transplant is 1.5 mg/kg of body weight administered daily for 7 to 14 days.