What protein contains cadherin-11?
Table of Contents
The extracellular domain consists of 5 subdomains, each of which contains a cadherin-specific motif. Cadherin expression is regulated spatially as well as temporally….Cadherin-11 Gene family protein.
| Approved symbol | Common name |
|---|---|
| CDH18 | CDH18 protein, recombinant |
| CDH5 | VE-Cadherin protein, recombinant |
What is the primary function of cadherin?
Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis.
What is cadherin anatomy?
cadherin: Any of a class of transmembrane proteins important in maintaining tissue structure. adherens junctions: Protein complexes that occur at cell–cell junctions in epithelial tissues; they are usually more basal than tight junctions. catenin: Any of a class of proteins that have a role in cell adhesion.
What is the function of N-cadherin?
N-Cadherin belongs to a superfamily of calcium-dependent transmembrane adhesion proteins. It mediates adhesion in the intercalated discs at the termini of cardiomyocytes thereby serving as anchor for myofibrils at cell-cell contacts.
Why are there different types of cadherins?
Cadherins are Ca2+ dependent cell-cell adhesion molecules that mediate adhesion between cells and tissues in organisms. They are differentiated into several types based on their location and properties.
Can mAb targeted against Cadherin-11 reduce inflammation in fibroblasts?
Previously, we found that fibroblasts can be targeted by mAb directed against cadherin-11 (cad-11), a mesenchymal cadherin that fibroblasts selectively express. Targeting cad-11 significantly reduced inflammation as assessed by joint swelling and clinical inflammation scores.
How does anti-cad-11 reduce inflammation?
Targeting cad-11 significantly reduced inflammation as assessed by joint swelling and clinical inflammation scores. However, the mechanism by which anti-cad-11 reduced inflammation was not known.
What is the role of fibroblasts in the pathogenesis of inflammation?
Fibroblasts are important participants in inflammation. Although not leukocytes, their capacity to produce cytokines, chemokines, and other inflammatory factors locally in tissues suggests that they can contribute to inflammatory diseases.